The U.S. Chamber of Commerce is paving the way to unseat “obstructionist” Republicans in the House who have successfully blocked much of the organization’s agenda.

The move is spurred by Chamber frustration after the group poured nearly $70 million into the 2014 election to strengthen the Republican coalition in the Senate, only to have its efforts thwarted in the House, Politico reported Friday.

The Chamber intends to primary sitting House conservatives who have halted many of its legislative priorities, including immigration reform, the Export-Import Bank’s renewal and a long-term highway bill.

Source: Chamber of Commerce Ready to Primary House Conservatives